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The Domain Name System (DNS) is among the most ubiquitous and important protocols for network communication; however, security concerns regarding DNS have been on the rise and demand for encrypted traffic has followed suit. Using a publicly available dataset, this work compares 10 different machine learning classifiers using stratified 10-fold cross-validation. The classifiers are used to determine the most effective and efficient way of detecting malicious DNS over Hypertext Transfer Protocol Secure (HTTPS) traffic, dubbed DoH traffic. Model performance is evaluated on Non-DoH vs. DoH traffic, then tested on benign vs. malicious DoH traffic. Additionally, this paper seeks to build upon existing research by removing noise and introducing feature selection methods and feature explainability to produce a better model for real-world deployment. After eliminating five overfitting features, our findings indicate that …