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2.3. 1. Molecular basis of education 15 2.3. 1.1. 1. Classical MHC class I dependent education 15 Human natural killer cells in major histocompatibility complex class I deficiency 16 2.3. 1.2. Non-classical MHC class I dependent education 19 2.3. 1.3. MHC class I independent education 19 2.3. 2. Models of NK cell education 20 2.3. 2.1. Licensing and arming 20 2.3. 2.2. Disarming 22 2.3. 2.3. Rheostat model 22 2.3. 2.4. Confining model 22 2.3. 2.5. Cis-and Trans-interactions 23 2.4. Functions of NK cells 24 2.4. 1. NK cells in cancer 25 2.4. 2. NK cells and viruses 26 2.4. 3. NK cells and bacterial infections 27 Airway Natural Killer Cells and Bacteria in Health and Disease 28 3. Revisiting the Functional Impact of NK Cells 43 4. Mucosal associated invariant T cells 57