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Cross-docking practice plays an important role in improving the efficiency of distribution networks, especially, for optimizing supply chain operations. Moreover, transportation route planning, controlling the Greenhouse Gas (GHG) emissions and customer satisfaction constitute the major parts of the supply chain that need to be taken into account integratedly within a common framework. For this purpose, this paper tries to introduce the reliable Pollution-Routing Problem with Cross-dock Selection (PRP-CDS) where the products are processed and transported through at least one cross-dock. To formulate the problem, a Bi-Objective Mixed-Integer Linear Programming (BOMILP) model is developed, where the first objective is to minimize total cost including pollution and routing costs and the second is to maximize supply reliability. Accordingly, sustainable development of the supply chain is addressed. Due to the …