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Human health is rising under the fear of an emerging international health crisis where public health can be easily compromised. In this chapter, various factors that directly or indirectly target public health infrastructure and lead to global crisis like extreme climate changes, refugee health crisis, terrorism and technologyrelated incidents, are discussed. On analysis of the factors that may lead to such disasters, various challenges faced during the disasters are listed specifically pertaining to the healthcare system. The greater risk of disaster can be seen there, where there is a lack of basic amenities, limited access to healthcare, and lack of resources required to cope up from disease. In such situations, it becomes an utmost priority to contain infectious disease and prepare for epidemics, protecting adolescents, elevating health in the climate debate, and delivering healthcare in areas of conflict and crisis. Some of the …