作者
Hilde T Juvodden, Dag Alnæs, Martina J Lund, Ingrid Agartz, OIe A Andreassen, Andres Server, Per M Thorsby, Lars T Westlye, Stine Knudsen Heier
发表日期
2023/11/1
期刊
Sleep
卷号
46
期号
11
页码范围
zsad173
出版商
Oxford University Press
简介
Study Objectives
Narcolepsy type 1 (NT1) is a neurological sleep disorder. Postmortem studies have shown 75%–90% loss of the 50 000–70 000 hypocretin-producing neurons and 64%–94% increase in the 64 000–120 000 histaminergic neurons and conflicting indications of gliosis in the hypothalamus of NT1 patients. The aim of this study was to compare MRI-based volumes of the hypothalamus in patients with NT1 and controls in vivo.
Methods
We used a segmentation tool based on deep learning included in Freesurfer and computed the volume of the whole hypothalamus, left/right part of the hypothalamus, and 10 hypothalamic subregions. We included 54 patients with post-H1N1 NT1 (39 females, mean age 21.8 ± 11.0 years) and 114 controls (77 females, mean age 23.2 ± 9.0 years). Group differences were tested with general linear models using permutation testing in …
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HT Juvodden, D Alnæs, MJ Lund, I Agartz… - Sleep, 2023