作者
Irene Voldsbekk, Rikka Kjelkenes, Andreas Dahl, Madelene C Holm, Martina J Lund, Tobias Kaufmann, Christian K Tamnes, Ole A Andreassen, Lars T Westlye, Dag Alnæs
发表日期
2023/8/1
期刊
Developmental Cognitive Neuroscience
卷号
62
页码范围
101271
出版商
Elsevier
简介
The interplay between functional brain network maturation and psychopathology during development remains elusive. To establish the structure of psychopathology and its neurobiological mechanisms, mapping of both shared and unique functional connectivity patterns across developmental clinical populations is needed. We investigated shared associations between resting-state functional connectivity and psychopathology in children and adolescents aged 5–21 (n = 1689). Specifically, we used partial least squares (PLS) to identify latent variables (LV) between connectivity and both symptom scores and diagnostic information. We also investigated associations between connectivity and each diagnosis specifically, controlling for other diagnosis categories. PLS identified five significant LVs between connectivity and symptoms, mapping onto the psychopathology hierarchy. The first LV resembled a general …
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