作者
Eshim S Jami, Anke R Hammerschlag, Hill F Ip, Andrea G Allegrini, Beben Benyamin, Richard Border, Elizabeth W Diemer, Chang Jiang, Ville Karhunen, Yi Lu, Qing Lu, Travis T Mallard, Pashupati P Mishra, Ilja M Nolte, Teemu Palviainen, Roseann E Peterson, Hannah M Sallis, Andrey A Shabalin, Ashley E Tate, Elisabeth Thiering, Natàlia Vilor-Tejedor, Carol Wang, Ang Zhou, Daniel E Adkins, Silvia Alemany, Helga Ask, Qi Chen, Robin P Corley, Erik A Ehli, Luke M Evans, Alexandra Havdahl, Fiona A Hagenbeek, Christian Hakulinen, Anjali K Henders, Jouke Jan Hottenga, Tellervo Korhonen, Abdullah Mamun, Shelby Marrington, Alexander Neumann, Kaili Rimfeld, Fernando Rivadeneira, Judy L Silberg, Catharina E van Beijsterveldt, Eero Vuoksimaa, Alyce M Whipp, Xiaoran Tong, Ole A Andreassen, Dorret I Boomsma, Sandra A Brown, S Alexandra Burt, William Copeland, Danielle M Dick, K Paige Harden, Kathleen Mullan Harris, Catharina A Hartman, Joachim Heinrich, John K Hewitt, Christian Hopfer, Elina Hypponen, Marjo-Riitta Jarvelin, Jaakko Kaprio, Liisa Keltikangas-Järvinen, Kelly L Klump, Kenneth Krauter, Ralf Kuja-Halkola, Henrik Larsson, Terho Lehtimäki, Paul Lichtenstein, Sebastian Lundström, Hermine H Maes, Per Magnus, Marcus R Munafò, Jake M Najman, Pål R Njølstad, Albertine J Oldehinkel, Craig E Pennell, Robert Plomin, Ted Reichborn-Kjennerud, Chandra Reynolds, Richard J Rose, Andrew Smolen, Harold Snieder, Michael Stallings, Marie Standl, Jordi Sunyer, Henning Tiemeier, Sally J Wadsworth, Tamara L Wall, Andrew JO Whitehouse, Gail M Williams, Eivind Ystrøm, Michel G Nivard, Meike Bartels, Christel M Middeldorp
发表日期
2022/7/1
期刊
Journal of the American Academy of Child & Adolescent Psychiatry
卷号
61
期号
7
页码范围
934-945
出版商
Elsevier
简介
Objective
To investigate the genetic architecture of internalizing symptoms in childhood and adolescence.
Method
In 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated assessments of internalizing symptoms, in a total of 64,561 children and adolescents between 3 and 18 years of age. Results were aggregated in meta-analyses that accounted for sample overlap, first using all available data, and then using subsets of measurements grouped by rater, age, and instrument.
Results
The meta-analysis of overall internalizing symptoms (INToverall) detected no genome-wide significant hits and showed low single nucleotide polymorphism (SNP) heritability (1.66%, 95% CI = 0.84-2.48%, neffective = 132,260). Stratified analyses indicated rater-based heterogeneity in genetic effects, with self-reported internalizing symptoms showing the highest heritability (5.63%, 95 …
学术搜索中的文章
ES Jami, AR Hammerschlag, HF Ip, AG Allegrini… - Journal of the American Academy of Child & …, 2022