作者
Wonuola A Akingbuwa, Anke R Hammerschlag, Eshim S Jami, Andrea G Allegrini, Ville Karhunen, Hannah Sallis, Helga Ask, Ragna B Askeland, Bart Baselmans, Elizabeth Diemer, Fiona A Hagenbeek, Alexandra Havdahl, Jouke-Jan Hottenga, Hamdi Mbarek, Fernando Rivadeneira, Martin Tesli, Catharina Van Beijsterveldt, Gerome Breen, Cathryn M Lewis, Anita Thapar, Dorret I Boomsma, Ralf Kuja-Halkola, Ted Reichborn-Kjennerud, Per Magnus, Kaili Rimfeld, Eivind Ystrom, Marjo-Riitta Jarvelin, Paul Lichtenstein, Sebastian Lundstrom, Marcus R Munafò, Robert Plomin, Henning Tiemeier, Michel G Nivard, Meike Bartels, Christel M Middeldorp
发表日期
2020/7/1
期刊
JAMA psychiatry
卷号
77
期号
7
页码范围
715-728
出版商
American Medical Association
简介
Importance
Adult mood disorders are often preceded by behavioral and emotional problems in childhood. It is yet unclear what explains the associations between childhood psychopathology and adult traits.
Objective
To investigate whether genetic risk for adult mood disorders and associated traits is associated with childhood disorders.
Design, Setting, and Participants
This meta-analysis examined data from 7 ongoing longitudinal birth and childhood cohorts from the UK, the Netherlands, Sweden, Norway, and Finland. Starting points of data collection ranged from July 1985 to April 2002. Participants were repeatedly assessed for childhood psychopathology from ages 6 to 17 years. Data analysis occurred from September 2017 to May 2019.
Exposures
Individual polygenic scores (PGS) were constructed in children based on genome-wide association studies of adult major depression, bipolar disorder, subjective well …
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WA Akingbuwa, AR Hammerschlag, ES Jami… - JAMA psychiatry, 2020