作者
Dina Mansour Aly, Om Prakash Dwivedi, Rashmi B Prasad, Annemari Käräjämäki, Rebecka Hjort, Manonanthini Thangam, Mikael Åkerlund, Anubha Mahajan, Miriam S Udler, Jose C Florez, Mark I McCarthy, Regeneron Genetics Center RGC Management and Leadership Team Abecasis Goncalo 17 Baras Aris 17 Cantor Michael 17 Coppola Giovanni 17 Economides Aris 17 Lotta Luca A. 17 Overton John D. 17 Reid Jeffrey G. 17 Shuldiner Alan 17, Genome Informatics Bai Xiaodong 17 Balasubramanian Suganthi 17 Blumenfeld Andrew 17 Eom Gisu 17 Habegger Lukas 17 Hawes Alicia 17 Khalid Shareef 17 Maxwell Evan K. 17 Salerno William 17 Staples Jeffrey C. 17, Research Program Management Jones Marcus B. 17 Mitnaul Lyndon J. 17
发表日期
2021/11
期刊
Nature genetics
卷号
53
期号
11
页码范围
1534-1542
出版商
Nature Publishing Group US
简介
Type 2 diabetes has been reproducibly clustered into five subtypes with different disease progression and risk of complications; however, etiological differences are unknown. We used genome-wide association and genetic risk score (GRS) analysis to compare the underlying genetic drivers. Individuals from the Swedish ANDIS (All New Diabetics In Scania) study were compared to individuals without diabetes; the Finnish DIREVA (Diabetes register in Vasa) and Botnia studies were used for replication. We show that subtypes differ with regard to family history of diabetes and association with GRS for diabetes-related traits. The severe insulin-resistant subtype was uniquely associated with GRS for fasting insulin but not with variants in the TCF7L2 locus or GRS reflecting insulin secretion. Further, an SNP (rs10824307) near LRMDA was uniquely associated with mild obesity-related diabetes. Therefore, we conclude …
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D Mansour Aly, OP Dwivedi, RB Prasad, A Käräjämäki… - Nature genetics, 2021