作者
Marjolein EA Barendse, Julian G Simmons, George Patton, Lisa Mundy, Michelle L Byrne, Marc L Seal, Nicholas B Allen, Sarah Whittle
发表日期
2020/6/1
期刊
Journal of the American Academy of Child & Adolescent Psychiatry
卷号
59
期号
6
页码范围
739-748. e2
出版商
Elsevier
简介
Objective
This study aimed to examine longitudinally whether adrenarcheal timing (adrenarcheal hormone levels independent of age) and tempo (change in hormone levels over time) were associated with amygdala functional connectivity and how this in turn related to anxiety symptoms in the transition from childhood to adolescence.
Method
Participants were 64 children (34 girls) who completed the Spence Children’s Anxiety Scale and saliva collections to measure levels of testosterone, dehydroepiandrosterone, and dehydroepiandrosterone sulfate at two time points (mean age 9.5 years at time 1 [T1], 12.2 years at time 2 [T2]). Participants also viewed fearful and calm facial expressions while undergoing functional magnetic resonance imaging scanning at both time points. Amygdala functional connectivity was assessed with psychophysiological interaction analysis and modeled longitudinally with the Multivariate …
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MEA Barendse, JG Simmons, G Patton, L Mundy… - Journal of the American Academy of Child & …, 2020