作者
Stefan J Borgwardt, Paul Allen, Sagnik Bhattacharyya, Paolo Fusar-Poli, Jose A Crippa, Marc L Seal, Valter Fraccaro, Zerrin Atakan, Rocio Martin-Santos, Colin O'Carroll, Katya Rubia, Philip K McGuire
发表日期
2008/12/1
期刊
Biological psychiatry
卷号
64
期号
11
页码范围
966-973
出版商
Elsevier
简介
BACKGROUND
This study examined the effect of Δ-9-tetrahydrocannabinol (Δ-9-THC) and cannabidiol (CBD) on brain activation during a motor inhibition task.
METHODS
Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either Δ-9-THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design.
RESULTS
Relative to placebo, Δ-9-THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms.
CONCLUSIONS
These data suggest that Δ-9-THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in …
引用总数
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