作者
Paolo Fusar-Poli, José A Crippa, Sagnik Bhattacharyya, Stefan J Borgwardt, Paul Allen, Rocio Martin-Santos, Marc Seal, Simon A Surguladze, Colin O’Carrol, Zerrin Atakan, Antonio W Zuardi, Philip K McGuire
发表日期
2009/1/1
期刊
Archives of general psychiatry
卷号
66
期号
1
页码范围
95-105
出版商
American Medical Association
简介
Context
Cannabis use can both increase and reduce anxiety in humans. The neurophysiological substrates of these effects are unknown.
Objective
To investigate the effects of 2 main psychoactive constituents ofCannabis sativa(Δ9-tetrahydrocannabinol [Δ9-THC] and cannabidiol [CBD]) on regional brain function during emotional processing.
Design
Subjects were studied on 3 separate occasions using an event-related functional magnetic resonance imaging paradigm while viewing faces that implicitly elicited different levels of anxiety. Each scanning session was preceded by the ingestion of either 10 mg of Δ9-THC, 600 mg of CBD, or a placebo in a double-blind, randomized, placebo-controlled design.
Participants
Fifteen healthy, English-native, right-handed men who had used cannabis 15 times or less in their life.
Main Outcome Measures
Regional brain activation (blood oxygenation level–dependent response …
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