查看文章

Central nervous system deficits are well described in type 1 diabetes (T1D); however the brain regions most affected and the underlying neurobiological mechanisms remain unclear. This prospective study aimed to use functional MRI (fMRI) and a working memory task (WMT) to assess changes in brain function between euglycemia (5.0 ± 0.5mmol/l) and hypoglycemia (2.6 ± 0.5mmol/l) or hyperglycemia (18-20 ± 0.5 mmol/l) in youth aged 12-18 y with T1D. Exclusion criteria: HbA1c > 9.0%, IQ < 70, prior history of DKA, seizure, neurological disease or substance abuse.