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As of April 27, 2020, the coronavirus disease 2019 (COVID-19) pandemic involved 2,916,338 reported cases and had claimed 205,923 lives. 1 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading in almost every country, causing widespread health challenges and social instability. People most vulnerable to COVID-19 include those with underlying health conditions. 2 Yet the pandemic is disrupting clinical trials addressing these same health conditions. 3 There were more than 300,000 studies being conducted worldwide registered on clinicaltrials. gov. in March 2020. 4 Hence, there is a necessity to continue some ongoing research studies safely, a critical need for novel research into the prevention and treatment of COVID-19, and we must try to anticipate the ethical and social implications of this global pandemic. This commentary is directed at these two pressing ethical questions: How …