作者
Jeffrey C Andrews, Holger J Schünemann, Andrew D Oxman, Kevin Pottie, Joerg J Meerpohl, Pablo Alonso Coello, David Rind, Victor M Montori, Juan Pablo Brito, Susan Norris, Mahmoud Elbarbary, Piet Post, Mona Nasser, Vijay Shukla, Roman Jaeschke, Jan Brozek, Ben Djulbegovic, Gordon Guyatt
发表日期
2013/7/1
期刊
Journal of clinical epidemiology
卷号
66
期号
7
页码范围
726-735
出版商
Pergamon
简介
In the GRADE approach, the strength of a recommendation reflects the extent to which we can be confident that the composite desirable effects of a management strategy outweigh the composite undesirable effects. This article addresses GRADE's approach to determining the direction and strength of a recommendation. The GRADE describes the balance of desirable and undesirable outcomes of interest among alternative management strategies depending on four domains, namely estimates of effect for desirable and undesirable outcomes of interest, confidence in the estimates of effect, estimates of values and preferences, and resource use. Ultimately, guideline panels must use judgment in integrating these factors to make a strong or weak recommendation for or against an intervention.
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