作者
Christof Angermueller, Stephen J Clark, Heather J Lee, Iain C Macaulay, Mabel J Teng, Tim Xiaoming Hu, Felix Krueger, Sébastien A Smallwood, Chris P Ponting, Thierry Voet, Gavin Kelsey, Oliver Stegle, Wolf Reik
发表日期
2016/3
期刊
Nature methods
卷号
13
期号
3
页码范围
229-232
出版商
Nature Publishing Group US
简介
We report scM&T-seq, a method for parallel single-cell genome-wide methylome and transcriptome sequencing that allows for the discovery of associations between transcriptional and epigenetic variation. Profiling of 61 mouse embryonic stem cells confirmed known links between DNA methylation and transcription. Notably, the method revealed previously unrecognized associations between heterogeneously methylated distal regulatory elements and transcription of key pluripotency genes.
学术搜索中的文章
C Angermueller, SJ Clark, HJ Lee, IC Macaulay… - Nature methods, 2016