作者
Mohsen Mazidi, Dimitri P Mikhailidis, Naveed Sattar, Peter P Toth, Suzanne Judd, Michael J Blaha, Adrian V Hernandez, Peter E Penson, Maciej Banach, International Lipid Expert Panel, Lipid and Blood Pressure Meta-analysis Collaboration
发表日期
2020/12/1
期刊
Clinical nutrition
卷号
39
期号
12
页码范围
3677-3686
出版商
Churchill Livingstone
简介
Background
Associations between dietary fats and mortality are unclear.
Methods
We evaluated the relationship between quartiles of total fat, mono-unsaturated (MUFA), polyunsaturated (PUFA) and saturated fatty acid (SFA) consumption, and all-cause, coronary heart disease (CHD), stroke, and type 2 diabetes (T2D)-associated mortality in 24,144 participants from the National Health and Nutrition Examination Surveys (NHANES) 1999–2010. We added our results to a meta-analysis based on searches until November 2018.
Results
In fully adjusted Cox-proportional hazard models in our prospective study, there was an inverse association between total fat (HR: 0.90, 95% confidence interval 0.82, 0.99, Q4 vs Q1) and PUFA (0.81, 0.78–0.84) consumption and all-cause mortality, whereas SFA were associated with the increased mortality (1.08, 1.04–1.11). In the meta-analysis of 29 prospective cohorts (n = 1,164,029 …
学术搜索中的文章
M Mazidi, DP Mikhailidis, N Sattar, PP Toth, S Judd… - Clinical nutrition, 2020