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Complex industrial processes are controlled by the local regulation controllers at the field level, and the setpoints for the regulation are usually made by manual decomposition of the overall economic objective according to the operators' experience. If a precise static process model can be built, real-time optimization (RTO) can be used to generate the setpoints. Nevertheless, since the aforementioned control structure is actually open-loop, the desired economic objective of the whole processes may not be tracked when disturbances exist. Aiming at solving this problem, a novel network based model predictive control method (MPC) for setpoints compensation is proposed in this paper. Firstly, a multivariable proportional integral (PI) controller is designed to perform the local regulation control. Secondly, a stochastic packet dropout model is adopted to characterize the measurement and human-in-the-loop delay effect …