作者
Akash Nag, Sunil Karforma
发表日期
2015/11/28
期刊
International Journal of Advanced Technology in Engineering and Science (IJATES)
卷号
3
期号
1 (Special Issue)
页码范围
348-354
简介
In this paper, we propose an algorithm that automatically generates a consensus motif identifying a protein family given an alignment of a set of protein sequences. The algorithm also assigns probabilistic scores to each amino-acid choice at each position in the sequence that will better aid in matching the motif against a protein database. Using aligned neurotoxin sequences from 91 species of Elapid snakes, the neurotoxin-motif generated by our algorithm successfully matched 175 proteins, including the 91 input proteins, in the UniProt database, most of which were also neurotoxins from other snake venoms.
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