作者
Donal T. Skelly, Adam C. Harding, Javier Gilbert-Jaramillo, Michael L. Knight, Stephanie Longet, Anthony Brown, Sandra Adele, Emily Adland, Helen Brown, Senthil Chinnakannan, Timothy Donnison, Mohammad Ali, Patpong Rongkard, Matthew Pace, Peny Zacharopoulou, Nicola Robinson, Anna Csala, Cathy De Lara, Claire L. Hutchings, Hema Mehta, Lian Ni Lee, Matthew Edmans, Carl-Philipp Hackstein, Prabhjeet Phalora, Wenqin Li, Eloise Phillips, Tom Malone, Ane Ogbe, Cecilia Jay, Timothy Tipoe, Tom Tipton, Lizzie Stafford, Alexander J. Mentzer, Síle A. Johnson, Ali Amini, Thomas Marjot, Stavros Dimitriadis, Beatrice Simmons, Alexandra Deeks, Sven Kerneis, Hibatullah Abuelgasim, Robert Wilson, Sarah R. Thomas, Adam Watson, Ahmed Alhussni, Joseph Cutteridge, Esme Weeks, Lucy Denly, Katy Lillie, Jennifer Holmes, Philppa C. Matthews, Denise O’Donnell, Tiong Tan, Schimanski Kit, Huang Lisa, Rijal Kuan-Ying A., Turtle Pramila, Thus Lance, de Silva
发表日期
2021
期刊
Nature Communications
卷号
12
期号
5061
简介
The extent to which immune responses to natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization with vaccines protect against variants of concern (VOC) is of increasing importance. Accordingly, here we analyse antibodies and T cells of a recently vaccinated, UK cohort, alongside those recovering from natural infection in early 2020. We show that neutralization of the VOC compared to a reference isolate of the original circulating lineage, B, is reduced: more profoundly against B.1.351 than for B.1.1.7, and in responses to infection or a single dose of vaccine than to a second dose of vaccine. Importantly, high magnitude T cell responses are generated after two vaccine doses, with the majority of the T cell response directed against epitopes that are conserved between the prototype isolate B and the VOC. Vaccination is required to generate high potency immune …
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DT Skelly, AC Harding, J Gilbert-Jaramillo, ML Knight… - Nature communications, 2021