作者
S Stringer, CC Minică, Karin JH Verweij, Hamdi Mbarek, M Bernard, Jaime Derringer, KR Van Eijk, JD Isen, Anu Loukola, Dominique F Maciejewski, E Mihailov, Peter J van der Most, C Sánchez-Mora, L Roos, R Sherva, R Walters, JJ Ware, A Abdellaoui, TB Bigdeli, Susan JT Branje, SA Brown, M Bruinenberg, M Casas, Tonu Esko, Iris García-Martinez, Scott D Gordon, Juliette M Harris, Catharina A Hartman, Anjali K Henders, Andrew C Heath, Ian B Hickie, M Hickman, CJ Hopfer, JJ Hottenga, AC Huizink, DE Irons, RS Kahn, T Korhonen, HR Kranzler, K Krauter, PAC van Lier, GH Lubke, Pamela AF Madden, Reedik Mägi, MK McGue, Sarah E Medland, Wim HJ Meeus, Michael B Miller, Grant W Montgomery, Michel G Nivard, Ilja M Nolte, Albertine J Oldehinkel, Zdenka Pausova, B Qaiser, Lydia Quaye, Josep Antoni Ramos-Quiroga, Vanesa Richarte, Richard J Rose, Jean Shin, MC Stallings, Alexander I Stiby, TL Wall, Margaret J Wright, HM Koot, T Paus, John K Hewitt, M Ribasés, Jaakko Kaprio, MP Boks, Harold Snieder, T Spector, MR Munafò, A Metspalu, J Gelernter, Dorret I Boomsma, William G Iacono, Nicholas G Martin, NA Gillespie, Eske M Derks, JM Vink
发表日期
2016/3
期刊
Translational psychiatry
卷号
6
期号
3
页码范围
e769-e769
出版商
Nature Publishing Group
简介
Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. Individual differences in cannabis initiation are heritable (40–48%). The International Cannabis Consortium was established with the aim to identify genetic risk variants of cannabis use. We conducted a meta-analysis of genome-wide association data of 13 cohorts (N= 32 330) and four replication samples (N= 5627). In addition, we performed a gene-based test of association, estimated single-nucleotide polymorphism (SNP)-based heritability and explored the genetic correlation between lifetime cannabis use and cigarette use using LD score regression. No individual SNPs reached genome-wide significance. Nonetheless, gene-based tests identified four genes …
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S Stringer, CC Minică, KJH Verweij, H Mbarek… - Translational psychiatry, 2016