作者
Andries T Marees, Hilde de Kluiver, Sven Stringer, Florence Vorspan, Emmanuel Curis, Cynthia Marie‐Claire, Eske M Derks
发表日期
2018/6
来源
International journal of methods in psychiatric research
卷号
27
期号
2
页码范围
e1608
简介
Objectives
Genome‐wide association studies (GWAS) have become increasingly popular to identify associations between single nucleotide polymorphisms (SNPs) and phenotypic traits. The GWAS method is commonly applied within the social sciences. However, statistical analyses will need to be carefully conducted and the use of dedicated genetics software will be required. This tutorial aims to provide a guideline for conducting genetic analyses.
Methods
We discuss and explain key concepts and illustrate how to conduct GWAS using example scripts provided through GitHub (https://github.com/MareesAT/GWA_tutorial/).
In addition to the illustration of standard GWAS, we will also show how to apply polygenic risk score (PRS) analysis. PRS does not aim to identify individual SNPs but aggregates information from SNPs across the genome in order to provide individual‐level scores of genetic risk.
Results
The …
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学术搜索中的文章
AT Marees, H de Kluiver, S Stringer, F Vorspan, E Curis… - International journal of methods in psychiatric research, 2018