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Capturing ground truth data to benchmark super-resolution (SR) is challenging. Therefore, current quantitative studies are mainly evaluated on simulated data artificially sampled from ground truth images. We argue that such evaluations overestimate the actual performance of SR methods compared to their behavior on real images. Toward bridging this simulated-to-real gap, we introduce the Super-Resolution Erlangen (SupER) database, the first comprehensive laboratory SR database of all-real acquisitions with pixel-wise ground truth. It consists of more than 80k images of 14 scenes combining different facets: CMOS sensor noise, real sampling at four resolution levels, nine scene motion types, two photometric conditions, and lossy video coding at five levels. As such, the database exceeds existing benchmarks by an order of magnitude in quality and quantity. This paper also benchmarks 19 popular single …