作者
Paola Dongiovanni, Anna Ludovica Fracanzani, Silvia Fargion, Luca Valenti
发表日期
2011/10/1
来源
Journal of hepatology
卷号
55
期号
4
页码范围
920-932
出版商
Elsevier
简介
The dysmetabolic iron overload syndrome (DIOS) is now a frequent finding in the general population, as is detected in about one third of patients with nonalcoholic fatty liver disease (NAFLD) and the metabolic syndrome. The pathogenesis is related to altered regulation of iron transport associated with steatosis, insulin resistance, and subclinical inflammation, often in the presence of predisposing genetic factors. Evidence is accumulating that excessive body iron plays a causal role in insulin resistance through still undefined mechanisms that probably involve a reduced ability to burn carbohydrates and altered function of adipose tissue. Furthermore, DIOS may facilitate the evolution to type 2 diabetes by altering beta-cell function, the progression of cardiovascular disease by contributing to the recruitment and activation of macrophages within arterial lesions, and the natural history of liver disease by inducing …
学术搜索中的文章
P Dongiovanni, AL Fracanzani, S Fargion, L Valenti - Journal of hepatology, 2011