作者
Rosellina Margherita Mancina, Paola Dongiovanni, Salvatore Petta, Piero Pingitore, Marica Meroni, Raffaela Rametta, Jan Borén, Tiziana Montalcini, Arturo Pujia, Olov Wiklund, George Hindy, Rocco Spagnuolo, Benedetta Maria Motta, Rosaria Maria Pipitone, Antonio Craxì, Silvia Fargion, Valerio Nobili, Pirjo Käkelä, Vesa Kärjä, Ville Männistö, Jussi Pihlajamäki, Dermot F Reilly, Jose Castro-Perez, Julia Kozlitina, Luca Valenti, Stefano Romeo
发表日期
2016/5/1
期刊
Gastroenterology
卷号
150
期号
5
页码范围
1219-1230. e6
出版商
WB Saunders
简介
Background & Aims
Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver damage and is characterized by steatosis. Genetic factors increase risk for progressive NAFLD. A genome-wide association study showed that the rs641738 C>T variant in the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also called LPIAT1) and transmembrane channel-like 4 gene (TMC4) increased the risk for cirrhosis in alcohol abusers. We investigated whether the MBOAT7−TMC4 is a susceptibility locus for the development and progression of NAFLD.
Methods
We genotyped rs641738 in DNA collected from 3854 participants from the Dallas Heart Study (a multi-ethnic population-based probability sample of Dallas County residents) and 1149 European individuals from the Liver Biopsy Cross-Sectional Cohort. Clinical and anthropometric data were collected, and …
学术搜索中的文章
RM Mancina, P Dongiovanni, S Petta, P Pingitore… - Gastroenterology, 2016