作者
Paola Dongiovanni, Salvatore Petta, Ville Mannisto, Rosellina Margherita Mancina, Rosaria Pipitone, Vesa Karja, Marco Maggioni, Pirjo Kakela, Olov Wiklund, Enrico Mozzi, Stefania Grimaudo, Dorota Kaminska, Raffaela Rametta, Antonio Craxi, Silvia Fargion, Valerio Nobili, Stefano Romeo, Jussi Pihlajamaki, Luca Valenti
发表日期
2015/9/1
期刊
Journal of hepatology
卷号
63
期号
3
页码范围
705-712
出版商
Elsevier
简介
Background & Aims
Excess hepatic free cholesterol contributes to the pathogenesis of non-alcoholic steatohepatitis, and statins reduce cholesterol synthesis. Aim of this study was to assess whether statin use is associated with histological liver damage related to steatohepatitis.
Methods
The relationship between statin use, genetic risk factors, and liver damage was assessed in a multi-center cohort of 1201 European individuals, who underwent liver biopsy for suspected non-alcoholic steatohepatitis.
Results
Statin use was recorded in 107 subjects, and was associated with protection from steatosis, NASH, and fibrosis stage F2-F4, in a dose-dependent manner (adjusted p <0.05 for all). In 100 treated patients matched 1:1 for modality of recruitment, gender, presence of IFG or type 2 diabetes, PNPLA3 I148M risk alleles, TM6SF2 E167K variant, age, and BMI, statin use remained associated with protection from …
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