作者
Luca Valenti, Anna Ludovica Fracanzani, Elisabetta Bugianesi, Paola Dongiovanni, Enrico Galmozzi, Ester Vanni, Elena Canavesi, Ezio Lattuada, Giancarlo Roviaro, Giulio Marchesini, Silvia Fargion
发表日期
2010/3/1
期刊
Gastroenterology
卷号
138
期号
3
页码范围
905-912
出版商
WB Saunders
简介
BACKGROUND & AIMS
Mutations in the hemochromatosis gene (HFE) (C282Y and H63D) lead to parenchymal iron accumulation, hemochromatosis, and liver damage. We investigated whether these factors also contribute to the progression of fibrosis in patients with nonalcoholic fatty liver disease (NAFLD).
METHODS
We studied clinical, histologic (liver biopsy samples for hepatocellular iron accumulation), serologic (iron and enzyme levels), and genetic (HFE genotype) data from 587 patients from Italy with NAFLD and 184 control subjects.
RESULTS
Iron accumulation predominantly in hepatocyes was associated with a 1.7-fold higher risk of a fibrosis stage greater than 1 (95% confidence interval [CI]: 1.2–2.3), compared with the absence of siderosis (after adjustment for age, body mass index, glucose tolerance status, and alanine aminotransferase level). Nonparenchymal/mixed siderosis was not associated …
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L Valenti, AL Fracanzani, E Bugianesi, P Dongiovanni… - Gastroenterology, 2010