作者
Juha Rasanen, Matthew J Quinn, Amber Laurie, Eric Bean, Charles T Roberts Jr, Srinivasa R Nagalla, Michael G Gravett
发表日期
2015/1/1
期刊
American journal of obstetrics and gynecology
卷号
212
期号
1
页码范围
82. e1-82. e9
出版商
Mosby
简介
Objective
We assessed the association of glycosylated fibronectin (GlyFn) with preeclampsia and its performance in a point-of-care (POC) test.
Study Design
GlyFn, placental growth factor (PlGF), and soluble vascular endothelial growth factor receptor 1 (sFlt1) levels were determined in serum samples from 107 pregnant women. In all, 45 were normotensive and 62 were diagnosed with preeclampsia. The ability of GlyFn to assess preeclampsia status and relationships between GlyFn and maternal characteristics and pregnancy outcomes were analyzed.
Results
GlyFn serum levels in the first trimester were significantly higher in women with preeclampsia (P < .01) and remained higher throughout pregnancy (P < .01). GlyFn, sFlt1, PlGF, and the sFlt1/PlGF ratio were significantly associated (P < .01) with preeclampsia status, and the classification performance of these analytes represented by area under the receiver …
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J Rasanen, MJ Quinn, A Laurie, E Bean, CT Roberts Jr… - American journal of obstetrics and gynecology, 2015