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To study the interplay between age and culture as driver of self-employment motivation, we examine cross-sectional age differences (young to late adulthood) in self-employment desirability and feasibility beliefs across different cultures. We utilize individual-level data from the 2012 Flash Eurobarometer survey collected in 21 countries (total N = 13,963 individuals) and culture-level data from the GLOBE project. Our results from multi-level regression analyses show similar curvilinear lifespan patterns in both desirability and feasibility beliefs, with a peak in young adulthood and a strong decline toward late adulthood. This general pattern of age differences in these motivational factors, however, differs significantly across cultural dimensions of uncertainty avoidance, institutional collectivism and performance orientation. Notwithstanding the limitations of cross-sectional data, the present results indicate that …