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Sustainable development requires disruptive changes and radical innovations, and the capability to deliver this in relation to adapt to a sustainable development is needed in mature large industrial companies. Integration between sustainability and business development is needed, which the Circular Economy model offers. Circular Economy is little implemented in practice, and in the present paper barriers to a transition to Circular Economy is identified. Barriers are financial, structural, operational, attitudinal and technological. They are also, as analyzed in relation to innovation management, characterized by a need to increase integration between a number of different perspectives and domains in industry.