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We propose a new machine-learning approach for fiber-optic communication systems whose signal propagation is governed by the nonlinear Schrödinger equation (NLSE). Our main observation is that the popular split-step method (SSM) for numerically solving the NLSE has essentially the same functional form as a deep multi-layer neural network; in both cases, one alternates linear steps and pointwise nonlinearities. We exploit this connection by parameterizing the SSM and viewing the linear steps as general linear functions, similar to the weight matrices in a neural network. The resulting physics-based machine-learning model has several advantages over “black-box” function approximators. For example, it allows us to examine and interpret the learned solutions in order to understand why they perform well. As an application, low-complexity nonlinear equalization is considered, where the task is to efficiently …