作者
Kevin X Liu, Arlene Naranjo, Fan F Zhang, Steven G DuBois, Steve E Braunstein, Stephan D Voss, Geetika Khanna, Wendy B London, John J Doski, James D Geiger, Susan G Kreissman, Stephan A Grupp, Lisa R Diller, Julie R Park, Daphne A Haas-Kogan
发表日期
2020/8/20
期刊
Journal of clinical oncology: official journal of the American Society of Clinical Oncology
卷号
38
期号
24
页码范围
2741-2752
简介
PURPOSE
A primary objective of the Children’s Oncology Group (COG) ANBL0532 phase III study was to assess the effect of increasing local dose of radiation to a residual primary tumor on the cumulative incidence of local progression (CILP) in patients with high-risk neuroblastoma.
PATIENTS AND METHODS
Newly diagnosed patients with high-risk neuroblastoma were randomly assigned or assigned to receive single or tandem autologous stem-cell transplantation (SCT) after induction chemotherapy. Local control consisted of surgical resection during induction chemotherapy and radiotherapy after last SCT. Patients received 21.6 Gy to the preoperative primary tumor volume. For patients with incomplete surgical resection, an additional boost of 14.4 Gy was delivered to the gross residual tumor, for a total dose of 36 Gy. CILP (primary end point) and event-free (EFS) and overall survival (OS; secondary end points …
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KX Liu, A Naranjo, FF Zhang, SG DuBois… - Journal of Clinical Oncology, 2020