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To the authors' knowledge, the current study is the first national analysis of the association between preoperative platelet count and outcomes after craniotomy.

Patients who underwent craniotomy for tumor were extracted from the prospective National Surgical Quality Improvement Program registry (2007‐2014) and stratified by preoperative thrombocytopenia, defined as mild (125,000‐149,000/μL), moderate (100,000‐124,000/μL), severe (75,000‐99,000/μL), or very severe (<75,000/μL). Cox proportional hazards analysis was used to evaluate the association between thrombocytopenia and 30‐day mortality, and multivariable logistic regression with complications and unplanned reoperation. Covariates included patient age, sex, tumor histology, American Society of Anesthesiologists class, functional status, comorbidities, and surgical time.

A total of 14,852 patients were …