作者
Katerina M Antoniou, Andrew G Nicholson, Maria Dimadi, Katerina Malagari, Panagiota Latsi, Angeliki Rapti, Nikolaos Tzanakis, Rodoula Trigidou, Vlassis Polychronopoulos, Demosthenes Bouros
发表日期
2006/9/1
期刊
European Respiratory Journal
卷号
28
期号
3
页码范围
496-504
出版商
European Respiratory Society
简介
Idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonia is a deadly disease with no effective treatment. The purpose of this randomised prospective multicentric study was to characterise the clinical effects of interferon gamma (IFN-γ) 1b administered subcutaneously thrice weekly versus colchicine for 2 yrs. This study had no pre-specified end-points.
Fifty consecutive IPF patients were randomised. Patients with mild-to-moderate IPF were eligible for the study if they had histologically proven IPF, or, in the absence of surgical biopsy, fulfilled the European Respiratory Society/American Thoracic Society criteria.
In the intent-to-treat population, five out of 32 (15.6%) IFN-γ-1b patients and seven out of 18 (38.8%) colchicine patients died after a median follow-up period of 25 months Patients treated with IFN-γ 1b showed a better outcome after 2 yrs of therapy, and fewer symptoms, as assessed using the St …
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KM Antoniou, AG Nicholson, M Dimadi, K Malagari… - European Respiratory Journal, 2006