作者
Simon LF Walsh, Athol U Wells, Nicola Sverzellati, Gregory J Keir, Lucio Calandriello, Katerina M Antoniou, Susan J Copley, Anand Devaraj, Toby M Maher, Elizabetta Renzoni, Andrew G Nicholson, David M Hansell
发表日期
2014/2/1
期刊
The Lancet Respiratory Medicine
卷号
2
期号
2
页码范围
123-130
出版商
Elsevier
简介
Background
Mortality in pulmonary sarcoidosis is highly variable and a reliable prognostic algorithm for disease staging and for guiding management decisions is needed. The objective of this study is to derive and test a staging system for determining prognosis in pulmonary sarcoidosis.
Methods
We identified the prognostic value of high-resolution computed tomography (HRCT) patterns and pulmonary function tests, including the composite physiological index (CPI) in patients with pulmonary sarcoidosis. We integrated prognostic physiological and HRCT variables to form a clinical staging algorithm predictive of mortality in a test cohort. The staging system was externally validated in a separate cohort by the same methods of discrimination used in the primary analysis and tested for clinical applicability by four test observers.
Findings
The test cohort included 251 patients with pulmonary sarcoidosis in the study …
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SLF Walsh, AU Wells, N Sverzellati, GJ Keir… - The Lancet Respiratory Medicine, 2014