作者
Sallie R Permar, William J Moss, Judith J Ryon, Mwaka Monze, Felicity Cutts, Thomas C Quinn, Diane E Griffin
发表日期
2001/2/15
期刊
The Journal of infectious diseases
卷号
183
期号
4
页码范围
532-538
出版商
The University of Chicago Press
简介
A reverse transcriptase—polymerase chain reaction assay was used to detect measles virus RNA in peripheral blood mononuclear cells, urine, and nasopharyngeal specimens from Zambian children during hospitalization and ∼1–2 months after discharge. Of 47 children, 29 (61.7%) had prolonged measles virus shedding, as defined by detection of measles virus RNA in ⩾1 specimen obtained 30–61 days after rash onset. Ten (90.9%) of 11 human immunodeficiency virus (HIV)—infected children had prolonged measles virus shedding, compared with 19 (52.8%) of 36 HIV-uninfected children (P = .02). Prolonged measles virus shedding did not correlate with levels of measles virus—specific antibody. HIV-infected children with measles may have a prolonged infectious period that potentially enhances measles virus transmission and hinders measles control.
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SR Permar, WJ Moss, JJ Ryon, M Monze, F Cutts… - The Journal of infectious diseases, 2001