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This paper compares the practice of offshoring and backshoring of manufacturing from a supply chain innovation (SCI) perspective. The purpose is to advance the understanding of whether and how companies pursuing different globalisation strategies work differently with the SCI components, technology, and business processes. The results, based on a questionnaire survey in Denmark on relocation of manufacturing, indicate that companies reshoring manufacturing have invested more in manufacturing innovation and, to a higher degree, have reorganised their manufacturing resources compared with companies that either have offshored their manufacturing or maintained it at home.