作者
Amand F Schmidt, Mimount Bourfiss, Abdulrahman Alasiri, Esther Puyol-Anton, Sandesh Chopade, Marion van Vugt, Sander W van der Laan, Christian Gross, Chris Clarkson, Albert Henry, Tom R Lumbers, Pim van der Harst, Nora Franceschini, Joshua C Bis, Birgitta K Velthuis, Anneline SJM Te Riele, Aroon D Hingorani, Bram Ruijsink, Folkert W Asselbergs, Jessica van Setten, Chris Finan
发表日期
2023/4/26
期刊
Science advances
卷号
9
期号
17
页码范围
eadd4984
出版商
American Association for the Advancement of Science
简介
Dysfunction of either the right or left ventricle can lead to heart failure (HF) and subsequent morbidity and mortality. We performed a genome-wide association study (GWAS) of 16 cardiac magnetic resonance (CMR) imaging measurements of biventricular function and structure. Cis-Mendelian randomization (MR) was used to identify plasma proteins associating with CMR traits as well as with any of the following cardiac outcomes: HF, non-ischemic cardiomyopathy, dilated cardiomyopathy (DCM), atrial fibrillation, or coronary heart disease. In total, 33 plasma proteins were prioritized, including repurposing candidates for DCM and/or HF: IL18R (providing indirect evidence for IL18), I17RA, GPC5, LAMC2, PA2GA, CD33, and SLAF7. In addition, 13 of the 25 druggable proteins (52%; 95% confidence interval, 0.31 to 0.72) could be mapped to compounds with known oncological indications or side effects. These …
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AF Schmidt, M Bourfiss, A Alasiri, E Puyol-Anton… - Science advances, 2023