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Environmental pollution is a critical issue that requires proper measures to maintain environmental health in a sustainable and effective manner. The growing persistence of several active pharmaceutical residues, such as antibiotics like tetracycline, and anti-inflammatory drugs like diclofenac in water matrices is considered an issue of global concern. Numerous sewage/drain waste lines from the domestic and pharmaceutical sector contain an array of toxic compounds, so-called “emerging pollutants” and possess adverse effects on entire living ecosystem and damage its biodiversity. Therefore, effective solution and preventive measures are urgently required to sustainably mitigate and/or remediate pharmaceutically active emerging pollutants from environmental matrices. In this context, herein, the entry pathways of the pharmaceutical waste into the environment are presented, through the entire lifecycle of a …