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Severity estimation of obstructive sleep apnea (OSA) is currently based on the apnea–hypopnea index (AHI), which ignores individual breathing cessation event characteristics. Gender differences in the relationship between the breathing cessation event duration and the related desaturation event severity could mean that the severity of OSA is different in males and females despite a similar AHI. The aim of this work was to evaluate gender differences in the severity of peripheral oxygen desaturation events following obstructive apneas or hypopneas. Type I polysomnographic recordings of 220 males and 175 females were analyzed. The obstructive apnea and hypopnea events were divided into eight different durational categories from 10 s to 45 s with 5 s interval and> 45 s. The desaturation event severities following obstructive apneas or hypopneas were compared between genders within …