作者
David Beddow, Love Patel, Claire S Smith, Justin Kirven, Christine Schmidt, Daniel Ruppman, Rajesh Kethireddy, Michael Wankum, Barite Dawud, Catherine A St Hill
发表日期
2022/2/1
期刊
BMJ open
卷号
12
期号
2
页码范围
e050879
出版商
British Medical Journal Publishing Group
简介
Objective
To determine outcomes in hospitalised patients with sepsis and reported penicillin allergy (PcnA).
Design
Observational retrospective cohort study using data from electronic health records.
Setting
A large single health system with 11 hospitals of small, medium and large sizes including a 630-bed tertiary care teaching hospital.
Participants
Patients (n=5238) ≥18 years of age, hospitalised with sepsis, severe sepsis or septic shock between 1 January 2016 and 31 December 2018, received antibacterial agents, and had documented PcnA status. Patients <18 years of age at admission were excluded.
Outcome measures
Primary outcomes evaluated were inpatient mortality and 30-day mortality posthospital discharge. Secondary outcomes were hospital length of stay, 30-day readmissions, duration of antibiotic use, rate of Clostridium difficile infection and total cost of care.
Results
There was no difference in …
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D Beddow, L Patel, CS Smith, J Kirven, C Schmidt… - BMJ open, 2022