作者
Pamela Mahon, Nicholas Harvey, Sarah Crozier, Hazel Inskip, Sian Robinson, Nigel Arden, Rama Swaminathan, Cyrus Cooper, Keith Godfrey
发表日期
2010/1/1
期刊
Journal of Bone and Mineral Research
卷号
25
期号
1
页码范围
14-19
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Recent findings suggest that maternal vitamin D insufficiency during pregnancy has consequences for the offspring's bone health in later life. To investigate whether maternal vitamin D insufficiency affects fetal femur growth in ways similar to those seen in childhood rickets and study the timing during gestation of any effect of maternal vitamin D status, we studied 424 pregnant women within a prospective longitudinal study of maternal nutrition and lifestyle before and during pregnancy (Southampton Women's Survey). Using high‐resolution 3D ultrasound, we measured fetal femur length and distal metaphyseal cross‐sectional area, together with the ratio of femoral metaphyseal cross‐sectional area to femur length (femoral splaying index). Lower maternal 25‐hydroxyvitamin vitamin D concentration was not related to fetal femur length but was associated with greater femoral metaphyseal cross‐sectional area …
引用总数
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P Mahon, N Harvey, S Crozier, H Inskip, S Robinson… - Journal of Bone and Mineral Research, 2010