作者
Pau Farré, Meaghan J Jones, Michael J Meaney, Eldon Emberly, Gustavo Turecki, Michael S Kobor
发表日期
2015/12
期刊
Epigenetics & chromatin
卷号
8
页码范围
1-17
出版商
BioMed Central
简介
Background
DNA methylation is an epigenetic mark that balances plasticity with stability. While DNA methylation exhibits tissue specificity, it can also vary with age and potentially environmental exposures. In studies of DNA methylation, samples from specific tissues, especially brain, are frequently limited and so surrogate tissues are often used. As yet, we do not fully understand how DNA methylation profiles of these surrogate tissues relate to the profiles of the central tissue of interest.
Results
We have adapted principal component analysis to analyze data from the Illumina 450K Human Methylation array using a set of 17 individuals with 3 brain regions and whole blood. All of the top five principal components in our analysis were associated with a variable of interest: principal component 1 (PC1) differentiated brain from blood, PCs 2 and 3 were …
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P Farré, MJ Jones, MJ Meaney, E Emberly, G Turecki… - Epigenetics & chromatin, 2015