作者
Thomas W McDade, Calen P Ryan, Meaghan J Jones, Morgan K Hoke, Judith Borja, Gregory E Miller, Christopher W Kuzawa, Michael S Kobor
发表日期
2019/5
期刊
American journal of physical anthropology
卷号
169
期号
1
页码范围
3-11
出版商
John Wiley & Sons, Inc.
简介
Objectives
Socioeconomic status (SES) is a powerful determinant of health, but the underlying biological mechanisms are poorly understood. This study investigates whether levels of DNA methylation at CpG sites across the genome are associated with SES in a cohort of young adults in the Philippines.
Methods
DNA methylation was assayed with the Illumina HumanMethylation450 Bead Chip, in leukocytes from 489 participants in the Cebu Longitudinal Health and Nutrition Survey (mean age = 20.9 years). SES was measured in infancy/childhood and adulthood, and was based on composite measures of income, assets, and education. Genome‐wide analysis of variable probes identified CpG sites significantly associated with SES after adjustment for multiple comparisons. Functional enrichment analysis was used to identify biological pathways associated with these sites.
Results
A total of 2,546 CpG sites …
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TW McDade, CP Ryan, MJ Jones, MK Hoke, J Borja… - American journal of physical anthropology, 2019