作者
Samantha K Davis, Kevin John Selva, Ester Lopez, Ebene R Haycroft, Wen Shi Lee, Adam K Wheatley, Jennifer A Juno, Amy Adair, Phillip Pymm, Samuel J Redmond, Nicholas A Gherardin, Dale I Godfrey, Wai‐Hong Tham, Stephen J Kent, Amy W Chung
发表日期
2022
期刊
Clinical & Translational Immunology
卷号
11
期号
10
页码范围
e1424
简介
Objectives
Following infection with SARS‐CoV‐2, virus‐specific antibodies are generated, which can both neutralise virions and clear infection via Fc effector functions. The importance of IgG antibodies for protection and control of SARS‐CoV‐2 has been extensively reported. By comparison, other antibody isotypes including IgA have been poorly characterised.
Methods
Here, we characterised plasma IgA from 41 early convalescent COVID‐19 subjects for neutralisation and Fc effector functions.
Results
Convalescent plasma IgA from > 60% of the cohort had the capacity to inhibit the interaction between wild‐type RBD and ACE2. Furthermore, a third of the cohort induced stronger IgA‐mediated ACE2 inhibition than matched IgG when tested at equivalent concentrations. Plasma IgA and IgG from this cohort broadly recognised similar RBD epitopes and had similar capacities to inhibit ACE2 from binding to 22 of …
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SK Davis, KJ Selva, E Lopez, ER Haycroft, WS Lee… - Clinical & Translational Immunology, 2022