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The creep resistance of nickel-based superalloys at elevated temperature is inheritably correlated with interdiffusivity matrices, which are still difficult to be determined nowadays. In this work, the interdiffusion coefficient matrices of multicomponent nickel-based superalloys with seven alloying elements (ie, Al, Ti, Cr, Co, Mo, Ta and W) at 1553 K were determined in a high-throughput way by employing the diffusion multiple technique and HitDIC software. The results showed that the main interdiffusion coefficients D∼ A l A l N i and D∼ W W N i over the investigated composition space were the highest and lowest, respectively. Moreover, it was found that Al+ Ti is correlatedly accelerate the diffusion processes, while Mo+ Ta+ W has the tendency of decelerate the diffusion activities. Thereafter, the creep merit index of the concerned superalloys was evaluated using the measured interdiffusion coefficients, and the …