作者
Andrea Ganna, Karin JH Verweij, Michel G Nivard, Robert Maier, Robbee Wedow, Alexander S Busch, Abdel Abdellaoui, Shengru Guo, J Fah Sathirapongsasuti, 23andMe Research Team 16, Paul Lichtenstein, Sebastian Lundström, Niklas Långström, Adam Auton, Kathleen Mullan Harris, Gary W Beecham, Eden R Martin, Alan R Sanders, John RB Perry, Benjamin M Neale, Brendan P Zietsch
发表日期
2019/8/30
期刊
Science
卷号
365
期号
6456
页码范围
eaat7693
出版商
American Association for the Advancement of Science
简介
INTRODUCTION
Across human societies and in both sexes, some 2 to 10% of individuals report engaging in sex with same-sex partners, either exclusively or in addition to sex with opposite-sex partners. Twin and family studies have shown that same-sex sexual behavior is partly genetically influenced, but previous searches for the specific genes involved have been underpowered to detect effect sizes realistic for complex traits.
RATIONALE
For the first time, new large-scale datasets afford sufficient statistical power to identify genetic variants associated with same-sex sexual behavior (ever versus never had a same-sex partner), estimate the proportion of variation in the trait accounted for by all variants in aggregate, estimate the genetic correlation of same-sex sexual behavior with other traits, and probe the biology and complexity of the trait. To these ends, we performed genome-wide association discovery …
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