作者
Stéphanie M Van den Berg, Marleen HM de Moor, Karin JH Verweij, Robert F Krueger, Michelle Luciano, Alejandro Arias Vasquez, Lindsay K Matteson, Jaime Derringer, Tonu Esko, Najaf Amin, Scott D Gordon, Narelle K Hansell, Amy B Hart, Ilkka Seppälä, Jennifer E Huffman, Bettina Konte, Jari Lahti, Minyoung Lee, Mike Miller, Teresa Nutile, Toshiko Tanaka, Alexander Teumer, Alexander Viktorin, Juho Wedenoja, Abdel Abdellaoui, Goncalo R Abecasis, Daniel E Adkins, Arpana Agrawal, Jueri Allik, Katja Appel, Timothy B Bigdeli, Fabio Busonero, Harry Campbell, Paul T Costa, George Davey Smith, Gail Davies, Harriet de Wit, Jun Ding, Barbara E Engelhardt, Johan G Eriksson, Iryna O Fedko, Luigi Ferrucci, Barbara Franke, Ina Giegling, Richard Grucza, Annette M Hartmann, Andrew C Heath, Kati Heinonen, Anjali K Henders, Georg Homuth, Jouke-Jan Hottenga, William G Iacono, Joost Janzing, Markus Jokela, Robert Karlsson, John P Kemp, Matthew G Kirkpatrick, Antti Latvala, Terho Lehtimäki, David C Liewald, Pamela AF Madden, Chiara Magri, Patrik KE Magnusson, Jonathan Marten, Andrea Maschio, Hamdi Mbarek, Sarah E Medland, Evelin Mihailov, Yuri Milaneschi, Grant W Montgomery, Matthias Nauck, Michel G Nivard, Klaasjan G Ouwens, Aarno Palotie, Erik Pettersson, Ozren Polasek, Yong Qian, Laura Pulkki-Råback, Olli T Raitakari, Anu Realo, Richard J Rose, Daniela Ruggiero, Carsten O Schmidt, Wendy S Slutske, Rossella Sorice, John M Starr, Beate St Pourcain, Angelina R Sutin, Nicholas J Timpson, Holly Trochet, Sita Vermeulen, Eero Vuoksimaa, Elisabeth Widen, Jasper Wouda, Margaret J Wright, Lina Zgaga, Generation Scotland, David Porteous, Alessandra Minelli, Abraham A Palmer, Dan Rujescu, Marina Ciullo, Caroline Hayward, Igor Rudan, Andres Metspalu, Jaakko Kaprio, Ian J Deary, Katri Räikkönen, James F Wilson, Liisa Keltikangas-Järvinen, Laura J Bierut, John M Hettema, Hans J Grabe, Brenda WJH Penninx, Cornelia M van Duijn, David M Evans, David Schlessinger, Nancy L Pedersen, Antonio Terracciano, Matt McGue, Nicholas G Martin, Dorret I Boomsma
发表日期
2016/3
期刊
Behavior genetics
卷号
46
页码范围
170-182
出版商
Springer US
简介
Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but …
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SM Van den Berg, MHM de Moor, KJH Verweij… - Behavior genetics, 2016