作者
Christine M O’Brien, Kevin W Bishop, Haini Zhang, Xiao Xu, Leo Shmuylovich, Elizabeth Conley, Karen Nwosu, Kathleen Duncan, Suman B Mondal, Gail Sudlow, Samuel Achilefu
发表日期
2022/11/1
期刊
Biomedical Optics Express
卷号
13
期号
11
页码范围
5628-5642
出版商
Optica Publishing Group
简介
Quantifying solid tumor margins with fluorescence-guided surgery approaches is a challenge, particularly when using near infrared (NIR) wavelengths due to increased penetration depths. An NIR dual wavelength excitation fluorescence (DWEF) approach was developed that capitalizes on the wavelength-dependent attenuation of light in tissue to determine fluorophore depth. A portable dual wavelength excitation fluorescence imaging system was built and tested in parallel with an NIR tumor-targeting fluorophore in tissue mimicking phantoms, chicken tissue, and in vivo mouse models of breast cancer. The system showed high accuracy in all experiments. The low cost and simplicity of this approach make it ideal for clinical use.
学术搜索中的文章
CM O'Brien, KW Bishop, H Zhang, X Xu, L Shmuylovich… - Biomedical Optics Express, 2022