查看文章

Inflammation plays a role in prematurity, in neonatal disorders of the brain, lung, eye, bowel, and in developmental disability among preterm infants. We initiated a pilot study in preterm children to determine the prevalence of single nucleotide polymorphisms (SNPs) in the infection/inflammation-associated genes for interleukin (IL)-10 (-1082 G/A), IL-1β (+ 3953 C/T), tumor necrosis factor (TNF)-α (-308 G/A) and toll-like receptor 4 (TLR-4)(Asp299Gly) and whether these SNPs affect the risk for neonatal disorders. We genotyped 73 children≥ 2 years of age whose gestational age at birth was< 32 weeks, and explored the associations between genotypes and neonatal disorders and developmental status at age 2+ years. Infants homozygous for the high IL-10 producer-1082 G‐allele (n= 15) were significantly less likely to develop ultrasound-defined periventricular echodensities. A non …